In tests on healthy volunteers, researchers from the Baylor College of Medicine, Houston, Texas, USA, found that 38 per cent developed gastric ulcers when they took alendronate in combination with naproxen.
The randomized, crossover research involved 18 women and 8 men, aged between 30 and 50. During the trials, the volunteers took 10-day courses of each drug, and a 10-day course of the two drugs together.
Videoendoscopy was used to search for damage to the stomach, esophagus, or duodenal bulb.
"The combination appears synergistic" Dr David Graham
The researchers found that just 2 volunteers developed ulcers from taking alendronate and 3 were affected by naproxen. However, 10 developed problems after taking a combination of the two drugs.
Researchers, Dr David Graham and Dr Hoda Malaty write, "The combination appears synergistic. Alendronate should be used with caution in those who simultaneously require non-steroidal anti-inflammatory drugs."
Report Copyright: Englemed Health News at http://www.internationalmedicalnews.com