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 25 June 2018

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News

Polyethylene glycol 3350 without electrolytes for bowel preparation in children

Electrolyte-free polyethylene glycol 3350 is a safe and effective bowel preparation for children undergoing colonoscopy, find doctors in the latest issue of the Journal of Pediatrics.

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In this study, doctors from the United States assessed polyethylene glycol 3350 without electrolytes (PEG) for bowel preparation for colonoscopy in children.

The team performed a prospective study which included 46 children (mean age, 11.2 years). The children were given PEG at a dose of 1.5 g/kg/day for 4 days before colonoscopy.

The children were allowed to mix PEG in the beverage of their choice.

The team monitored stool frequency and adverse effects throughout the PEG therapy.

They also evaluated compliance, tolerance, and quality of colonic preparation

In addition, the doctors measured serum electrolytes before and after PEG therapy in 29 children.
Electrolyte profiles revealed insignificant changes.
Journal of Pediatrics

The doctors found that daily stool frequency increased with PEG therapy from a baseline of 2.6 on day 1, to 4.6 on day 2, 5.5 on day 3, and 6 on day 4. At endoscopy, the team rated the preparation as excellent or good in 91% and 95% for the right and left colon, respectively.

They found that mild nausea occurred in 13% of patients, abdominal pain in 11 %, and vomiting in 11%.

The children's electrolyte profile revealed insignificant changes with PEG therapy.

Furthermore, compliance and tolerance were rated as excellent by 89% and 85% of patients, respectively.

Dr Dinesh Pashankar's team concluded, "Electrolyte-free PEG 3350 can be used as an effective and safe bowel preparation that is well accepted by children for colonoscopy".

J Pediatrics 2004; 144(3):
15 March 2004

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