Obesity has been associated with a worse prognosis in acute pancreatitis.
However, there are few studies that have identified a relationship between obesity and mortality in acute pancreatitis.
In this study, researchers from Mexico and Spain evaluated the relationship between obesity and the outcome of acute pancreatitis by conducting a meta-analysis.
The team performed a Medline search that included the terms including obesity, body mass index (BMI) and pancreatitis.
|Severe acute pancreatitis was significantly more frequent in obese patients.|
They included studies performed between 1965 and 2002.
The team identified a total of 12 reports, however, only 4 of these included patients with mild and severe acute pancreatitis and measured obesity by BMI. A total of 607 patients were evaluated.
Obesity was defined when BMI was 30 kg/m2.
In addition, pooled odds ratio (OR) and confidence intervals (CI) were calculated according to the Mantel-Haenszel method. The team assessed heterogeneity by the multiplicative inverse variance method.
The researchers found that severe acute pancreatitis was significantly more frequent in obese patients (OR 2.6).
They determined that obese patients developed significantly more systemic (OR 2.0) and local complications (OR 4.3).
However, they found that mortality in obese patients was only slightly higher (OR 1.3).
Dr Martíneza's team concluded, "Obesity is a prognostic factor favoring the development of systemic and local complications in this disease".
"Therefore, it should be used routinely as part of the initial assessment of the severity of a case of acute pancreatitis".