The 13C-urea breath test (13C-UBT) is an accurate tool for diagnosis of Helicobacter pylori infection.
However, there are few studies evaluating the efficacy of this test in infants and toddlers.
In this study, researchers from Brazil assessed the 13C-UBT performed with infrared spectroscopy in children aged up to 6 years.
The team prospectively evaluated 68 patients, aged from 6 months to 5 years 11 months.
|Sensitivity was 93% and specificity 96%.|
They detected H. pylori infection by positive culture, or rapid urease test and histological examination.
The 13C-UBT was performed with 50 mg of 13C-urea diluted in 100 ml of commercial orange juice.
The team collected 2 expired air samples; before and 30 minutes after tracer ingestion.
The cutoff of delta over baseline (DOB) was 4.0 and urea hydrolysis rate 10 µg per minute.
The researchers determined that 22% of the patients were H. pylori positive.
The team determined that the sensitivity was 93% and specificity 96%. These values were equal for DOB and urea hydrolysis rate.
They found that negative DOB values in noninfected patients ranged from 1.5 to 2.6, while positive DOB values ranged from 10.8 to 105.5.
The team did not identify any relationship between DOB values and age.
Dr Rodrigo Strehl Machado's team concluded, "13C-UBT performed with infrared spectroscopy proved to be a reliable and accurate noninvasive diagnostic tool for H. pylori infection detection in children aged up to 6 years."
"Results far from cutoff value can clearly distinguish positive from negative 13C-UBT results in children up to 6 years old."