There is an association between diabetes and chronic liver disease. The temporal relationship between these conditions remains unknown.
In this study, researchers from the United States identified 173,643 patients diagnosed with diabetes between 1985 and 1990. They also randomly selected 650,620 patients without diabetes. Overall, 98% were male and the patients with diabetes were older (62 versus 54 years) than patients without diabetes.
Any patients with concomitant liver disease were excluded from the study.
The team followed the cohort until the end of 2000. They recorded the occurrence of chronic nonalcoholic liver disease and hepatocellular carcinoma.
The researchers determined that the incidence of chronic nonalcoholic liver disease was significantly higher in patients with diabetes.
This trend was similar for the occurrence of hepatocellular carcinoma.
|The highest risk was in patients with more than 10 years of follow-up.|
The team found that diabetes carried the highest risk among patients with more than 10 years of follow-up.
Dr Hashem El-Serag's team concluded, "Among men with diabetes, the risk of chronic nonalcoholic liver disease and hepatocellular carcinoma is doubled".
"This increase in risk is independent of alcoholic liver disease, viral hepatitis, or demographic features".