In this study, doctors from France examined the effect of smoking on ulcerative colitis and Crohn’s colitis. They also assessed the effect of gender on the response of colitis to smoking.
The team reviewed the medical charts of 1784 adult consecutive patients, whose smoking habits were specified by direct interview.
They found that the proportion of ever smokers was 42% in ulcerative colitis, 43% in indeterminate colitis, and 61% in Crohn’s colitis.
Smoking cessation preceded the onset of colitis in 61% of patients with ulcerative colitis or indeterminate colitis and 12% with Crohn’s colitis.
They determined that in ulcerative colitis and indeterminate colitis, current smoking delayed mean age at disease onset in men, but not women.
|Smoking cessation preceded the onset of ulcerative colitis in 61%.|
|Clinical Gastroenterology and Hepatology|
Current smoking also decreased the need for immunosuppressants in men, but not in women.
However, in Crohn’s colitis, the team found that current smoking hastened disease onset in women, but not men. It also increased the need for immunosuppressants in women, but not men.
Dr Jacques Cosnes's team concluded, "The dual effects of smoking in colitis, beneficial in ulcerative colitis and harmful in Crohn’s colitis, are modulated importantly by gender, with women having more disadvantage than men".