Wireless capsule enteroscopy (WCE) allows visualization of the entire small bowel and identification of superficial lesions not detected by traditional endoscopy and radiography.
In this study, investigators from Los Angeles, California, assessed the clinical utility of WCE in the evaluation of patients with known or suspected inflammatory bowel disease (IBD).
The team examined 50 patients with ongoing symptoms using a Given M2A endoscopic capsule.
Outcome measures were classified as diagnostic (multiple ulcerations), suspicious (3 ulcerations), nonspecific or normal.
The team determined that WCE findings were diagnostic for Crohn's disease (CD) in 20 patients and suspicious for small-bowel CD in 10.
They found that 17 of the patients with diagnostic WCE findings improved with increased IBD-directed medical therapy, as did 7 of those with suspicious study results.
WCE was normal or showed nonspecific findings in the remaining 20 patients.
The investigators found that the identification of lesions in 5 patients with a previous history of isolated colitis resulted in a change in diagnosis to CD.
Dr William Mow's team concluded, "WCE is a novel and potentially clinically useful method of directly visualizing and diagnosing small-bowel lesions in patients with IBD that can be missed by traditional endoscopic and radiological procedures".