Pierre Legrain, of the functional proteomics company Hybrigenics in Paris, France, and colleagues have identified and mapped some 1,200 interactions between proteins from Helicobacter pylori.
1,200 protein interactions have been identified and mapped
They have reported their findings in this week's issue of Nature.
The interactions connect almost half of the bacteria's 'proteome': the full protein set expressed by its genome.
Finding out what such proteins do - and how they do it - will put flesh on the bare bones of the decoded genomes of everything from H. pylori to humans.
Legrain's team screened 261 H. pylori 'bait' proteins against a much larger collection of 'prey' protein fragments. Both bait and prey were expressed inside yeast, which are modified to grow only if the two molecules interact.
Legrain said on behalf of the his colleagues that, "Analyzing the yeast colonies produced has already revealed which H. pylori proteins combine during urease synthesis, essential for the bug's pathogenesis."