Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 19 January 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Risks for advanced colonic neoplasia and hyperplastic polyps

Physicians in this week's issue of the Journal of the American Medical Association identify risk factors for advanced colonic neoplasia in asymptomatic individuals.

News image

fiogf49gjkf04

Identification of the risk factors for colorectal neoplasia may help in risk reduction. In this study, physicians from the United States determined the risk factors associated with advanced colorectal neoplasia in a cohort of asymptomatic individuals.

The team recruited 3121 asymptomatic patients (aged 50 to 75 years) from 13 medical centers.
Family history, smoking, and alcohol use are risk factors associated with advanced neoplasia.
Journal of the American Medical Association

All participants underwent complete colonoscopy to determine the prevalence of advanced neoplasia. This was defined as an adenoma that was ≥10 mm, a villous adenoma, an adenoma with high-grade dysplasia, or invasive cancer.

The physicians collected data on history of first-degree relative with colorectal cancer, prior cholecystectomy, serum cholesterol level, physical activity, smoking, alcohol use, and dietary factors.

They performed an age-adjusted analysis to calculate the odds ratios (ORs) of having advanced neoplasia, compared with having no polyps.

They also developed a multivariate logistic regression model to identify the most informative risk factors.

A secondary analysis examined risk factors for having hyperplastic polyps, compared with having no polyps, and compared with having advanced neoplasia.

The physicians found that 329 participants had advanced neoplasia, while 1441 had no polyps.

They identified that a first-degree relative with colorectal cancer (OR, 1.66), current smoking (OR, 1.85), and current moderate to heavy alcohol use (OR, 1.02) as risk factors associated with advanced neoplasia.

However, cereal fiber intake (OR, 0.95), vitamin D intake (OR, 0.94), and use of nonsteroidal anti-inflammatory drugs (NSAIDs) (OR, 0.66) were inversely associated.

Marginal factors included physical activity, daily multivitamin use, and intake of calcium and fat derived from red meat.

The team did not identify any association for body mass index, prior cholecystectomy, or serum cholesterol level.

In addition, 391 patients had hyperplastic polyps found at colonoscopy.

Risk variables were similar to those for patients with no polyps.

Dr David Lieberman's team concluded, "Our data endorse several important risk factors for advanced colonic neoplasia and provide a rationale for prudent risk reduction strategies".

"Further study is needed to determine if lifestyle changes can moderate the risk of colorectal cancer".

JAMA 2003; 290: 2959-67
11 December 2003

Go to top of page Email this page Email this page to a colleague

 19 January 2018 
Ileoanal pouch microbiota
 19 January 2018 
Predicting the risk of early surgery in Crohn’s
 19 January 2018 
Lifestyle intervention vs gastric bypass for obesity and diabetes
 18 January 2018 
Sleeve gastrectomy vs Roux-en-Y gastric bypass
 18 January 2018 
Healthcare costs of liver cancer in the USA
 18 January 2018 
High-risk adenomas at colonoscopy
 17 January 2018 
“Weekend effect” in upper GI hemorrhage
 17 January 2018 
Gut dysbiosis and non-antibiotic prescription medications
 17 January 2018 
Reducing surgical infections in high-outlier colorectal unit
 16 January 2018 
Bundle of care in GI cancer surgery
 16 January 2018 
Anxiety about colonoscopy
 16 January 2018 
Thiopurines and colorectal neoplasia in IBD
 15 January 2018 
Risks of death after liver transplants for liver cancer
 15 January 2018 
Recent advances in hepatocellular carcinoma
 15 January 2018 
Ileostomy output using telemedicine
 12 January 2018 
Surveillance protocols after colorectal cancer resection
 12 January 2018 
Biologic therapy by pregnant women with IBD and infant vaccines
 12 January 2018 
Biologic therapies for IBD in the USA
 11 January 2018 
Genetic risk factors in GERD
 11 January 2018 
Predictor of colorectal adenoma
 11 January 2018 
Ectopic pregnancy in IBD 
 10 January 2018 
Fecal immunochemical tests for colorectal cancer screening
 10 January 2018 
Risk factors for advanced NAFLD
 10 January 2018 
Dyspepsia prevalence with gastroesophageal reflux–type symptoms
 09 January 2018 
Screening intervals for people with family histories of colorectal cancer
 09 January 2018 
Financial impact of colorectal cancer
 09 January 2018 
Current practice and future research in autoimmune hepatitis
 08 January 2018 
Reliability of the IBD index
 08 January 2018 
Improving prognosis in patients with primary sclerosing cholangitis
 08 January 2018 
Aprepitant and nausea with gastroparesis
 05 January 2018 
Autoimmune pancreatitis and IBD
 05 January 2018 
Primary nonresponse to infliximab therapy
 05 January 2018 
Anesthesia assistance in outpatient colonoscopy
 04 January 2018 
Dietary polyphenols in the etiology of IBD
 04 January 2018 
Yoga vs low-FODMAP in IBS
 04 January 2018 
Local esophageal food allergen injections in eosinophilic esophagitis
 03 January 2018 
Population health management for IBD
 03 January 2018 
GERD in asthma and COPD
 03 January 2018 
Critical research gaps in colorectal cancer
 22 December 2017 
Costs of extrahepatic manifestations of Hep C
 22 December 2017 
Cholera vaccine and risk of death in colorectal cancer
 22 December 2017 
Colonoscopy after colorectal cancer resection
 21 December 2017 
Human oral microbiome and pancreatic cancer risk
 21 December 2017 
Health management for IBD
 21 December 2017 
PPI and Alzheimer's disease
 20 December 2017 
Management of abnormal liver blood tests
 20 December 2017 
Incidence of biopsy-verified celiac disease
 20 December 2017 
Osteoporotic fractures in Barrett's esophagus
 19 December 2017 
Alcohol abstinence and alcoholic hepatitis
 19 December 2017 
Family burden of pediatric Crohn's in the USA
 19 December 2017 
Early readmission in IBD patients
 18 December 2017 
Colorectal cancer mortality with low-risk adenomas at colonoscopy
 18 December 2017 
Disease activity indices in celiac disease
 18 December 2017 
Smoking behaviour predicted the risk of surgery in Crohn's
 15 December 2017 
Molecular classification of Crohn's disease
 15 December 2017 
Medical cannabinoid legalization policy and vomiting
 15 December 2017 
Inflammatory diet pattern and colorectal cancer risk
 14 December 2017 
PPIs and gastric cancer after H.pylori eradication
 14 December 2017 
H. pylori eradication therapies in countries with clarithromycin resistance
 13 December 2017 
Disease severity in NAFLD

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us