Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 19 April 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Risks for advanced colonic neoplasia and hyperplastic polyps

Physicians in this week's issue of the Journal of the American Medical Association identify risk factors for advanced colonic neoplasia in asymptomatic individuals.

News image

fiogf49gjkf04

Identification of the risk factors for colorectal neoplasia may help in risk reduction. In this study, physicians from the United States determined the risk factors associated with advanced colorectal neoplasia in a cohort of asymptomatic individuals.

The team recruited 3121 asymptomatic patients (aged 50 to 75 years) from 13 medical centers.
Family history, smoking, and alcohol use are risk factors associated with advanced neoplasia.
Journal of the American Medical Association

All participants underwent complete colonoscopy to determine the prevalence of advanced neoplasia. This was defined as an adenoma that was ≥10 mm, a villous adenoma, an adenoma with high-grade dysplasia, or invasive cancer.

The physicians collected data on history of first-degree relative with colorectal cancer, prior cholecystectomy, serum cholesterol level, physical activity, smoking, alcohol use, and dietary factors.

They performed an age-adjusted analysis to calculate the odds ratios (ORs) of having advanced neoplasia, compared with having no polyps.

They also developed a multivariate logistic regression model to identify the most informative risk factors.

A secondary analysis examined risk factors for having hyperplastic polyps, compared with having no polyps, and compared with having advanced neoplasia.

The physicians found that 329 participants had advanced neoplasia, while 1441 had no polyps.

They identified that a first-degree relative with colorectal cancer (OR, 1.66), current smoking (OR, 1.85), and current moderate to heavy alcohol use (OR, 1.02) as risk factors associated with advanced neoplasia.

However, cereal fiber intake (OR, 0.95), vitamin D intake (OR, 0.94), and use of nonsteroidal anti-inflammatory drugs (NSAIDs) (OR, 0.66) were inversely associated.

Marginal factors included physical activity, daily multivitamin use, and intake of calcium and fat derived from red meat.

The team did not identify any association for body mass index, prior cholecystectomy, or serum cholesterol level.

In addition, 391 patients had hyperplastic polyps found at colonoscopy.

Risk variables were similar to those for patients with no polyps.

Dr David Lieberman's team concluded, "Our data endorse several important risk factors for advanced colonic neoplasia and provide a rationale for prudent risk reduction strategies".

"Further study is needed to determine if lifestyle changes can moderate the risk of colorectal cancer".

JAMA 2003; 290: 2959-67
11 December 2003

Go to top of page Email this page Email this page to a colleague

 19 April 2018 
Fibrosis in patients with chronic hepatitis B
 19 April 2018 
c-Myc expression and pancreatic cancer
 19 April 2018 
Olmesartan prescription in the USA
 18 April 2018 
Online tool predicts bowel dysfunction severity prior to anterior resection
 18 April 2018 
Hep C treatment for sustained virologic response
 18 April 2018 
Endoscopic necrosectomy reduces risk of death 
 17 April 2018 
Colorectal cancer screening and ethnic inequities
 17 April 2018 
Training programs should consider radiation education for advanced endoscopy fellows
 17 April 2018 
Aspirin and pancreatic cancer
 16 April 2018 
Surgery for colorectal polyps has increased 
 16 April 2018 
Advanced fibrosis can be ruled out in primary health care patients
 16 April 2018 
Antibiotic use and colorectal adenoma
 13 April 2018 
Colorectal cancer cell lines
 13 April 2018 
Infliximab and corticosteroid-free clinical remission in Crohn's
 13 April 2018 
Teduglutide for children with short bowel syndrome
 12 April 2018 
Prescriptions for opiate drugs amongst primary care patients with IBD
 12 April 2018 
Lower GI bleeding related to comorbidity
 12 April 2018 
non–Clostridium difficile bacterial infections in IBD
 11 April 2018 
Physician perception of IBD trial results
 11 April 2018 
Bile acid deficiency in IBS 
 11 April 2018 
Stem cell therapy for fistulas in Crohn's
 10 April 2018 
Overweight in childhood and type 2 diabetes
 10 April 2018 
immunoglobulin G associates with clinical features of IBD
 10 April 2018 
T-cells repertoires in celiac disease
 09 April 2018 
Biomarker tests for colorectal cancer screening
 09 April 2018 
Fecal transplantation in C. difficile infection and treatment outcome 
 09 April 2018 
No weigh-loss drug improved all cardiometabolic risk factors
 06 April 2018 
Colonoscopy and colorectal cancer mortality
 06 April 2018 
Eosinophilic esophagitis and health-related quality of life
 06 April 2018 
Microbiome in athletes vs sedentary subjects
 05 April 2018 
Laparoscopic Nissen fundoplication for GERD treatment
 05 April 2018 
Random biopsies for neoplasia in IBD
 05 April 2018 
Scoring system identifies cancer risk in Barrett's
 04 April 2018 
Alpha‐1 antitrypsin deficiency and liver disease
 04 April 2018 
PPI and risk of stroke
 04 April 2018 
Adjuvant chemotherapy for advanced colon cancer
 29 March 2018 
Worldwide H.pylori prevalence
 29 March 2018 
Prevention of metachronous gastric cancer
 29 March 2018 
Acute lower GI bleeding
 28 March 2018 
Decision aid used by IBD patients
 28 March 2018 
Transition for young adults with IBD
 28 March 2018 
Amitriptyline in functional dyspepsia
 27 March 2018 
Emergency department utilization for IBD 
 27 March 2018 
Management of hemorrhoids in the USA
 27 March 2018 
Adult ulcerative colitis
 26 March 2018 
Biological therapy response in IBD 
 26 March 2018 
Obesity and diverticulosis
 26 March 2018 
Practice guidelines for chronic constipation
 23 March 2018 
Health-related quality of life in eosinophilic esophagitis
 23 March 2018 
Genetics and chronic liver disease
 23 March 2018 
Global prevalence of H.pylori
 22 March 2018 
H. pyloris and gastric cancer
 22 March 2018 
Pancreatitis after IBS treatment 
 22 March 2018 
Mechanisms of action in patients with IBS
 21 March 2018 
Panel markers for early detection of colon cancer

 21 March 2018 
Blood test differentiates celiac disease
 21 March 2018 
Patient characteristics and colonoscopy preparation
 20 March 2018 
Bloody vs coffee-grounds hematemesis
 20 March 2018 
Acute lower GI bleeding in the UK
 20 March 2018 
Therapeutic strategies for IBD

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us