Physicians from the United States have evaluated computed tomographic (CT) virtual colonoscopy for the detection of colorectal neoplasia in an average-risk screening population.
The study included 1233 asymptomatic adults with a mean age of 57.8 years, who underwent same-day virtual and optical colonoscopy.
The radiologists used the 3-dimensional endoluminal display for the initial detection of polyps on CT virtual colonoscopy.
For the initial examination, the colonoscopists were unaware of the findings on virtual colonoscopy.
|Both malignant polyps were detected on virtual colonoscopy.|
|New England Journal of Medicine|
The team calculated the sensitivity and specificity of virtual colonoscopy, and the sensitivity of optical colonoscopy, using the findings of a final, unblinded optical colonoscopy.
The physicians found that the sensitivity of virtual colonoscopy for adenomatous polyps was 94% for polyps ≥10 mm in diameter, 94% for polyps ≥8 mm, and 89% for polyps ≥ 6 mm.
In comparison, they found that the sensitivity of optical colonoscopy for adenomatous polyps was 88%, 92%, and 92%, respectively.
The team found that the specificity of virtual colonoscopy for adenomatous polyps was 96% for polyps ≥10 mm in diameter, 92% for polyps ≥8 mm in diameter, and 80% for polyps ≥6 mm in diameter.
Overall, 2 polyps were malignant. Both of these were detected on virtual colonoscopy. The team found that 1 was missed on optical colonoscopy.
Dr Perry Pickhardt's team concluded, "CT virtual colonoscopy with the use of a 3-dimensional approach is an accurate screening method for the detection of colorectal neoplasia".
It, "Compares favorably with optical colonoscopy in terms of the detection of clinically relevant lesions".