Approximately 35% of cases of iron deficiency anemia remain unexplained after a gastrointestinal evaluation.
There is a possible association between Helicobacter pylori and iron malabsorption.
In this study, researchers from France determined whether H. pylori-associated chronic gastritis is linked to unexplained iron deficiency anemia in adults.
|H. pylori-associated chronic gastritis:|
- patients = 60%
- controls = 43%
The team identified 105 patients with unexplained iron deficiency anemia.
They obtained 2 biopsies from the gastric antrum and 2 from the corpus of each patient.
Gastritis status was described according to the Sydney System.
The researchers assessed H. pylori infection using an immunohistochemical test on biopsy specimens.
Patients were compared with an age and sex matched control group.
The team identified H. pylori-associated chronic gastritis in 60% of patients and 43% of controls.
They determined that atrophic gastritis was significantly associated with iron deficiency anemia.
Dr Stéphane Nahon's team concluded, "H. pylori infection and chronic gastritis, especially atrophic gastritis, are significantly associated with unexplained iron deficiency anemia".
"Relationships between H. pylori-associated chronic gastritis and unexplained iron deficiency anemia should be considered".