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 17 January 2018

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News

Comparison of 18F-FDG PET and PET/CT for colorectal carcinoma

PET/CT imaging increases the accuracy and certainty of locating lesions in colorectal cancer, find investigators from Baltimore, Maryland.

News image

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In this study, investigators compared 18F-FDG PET and PET/CT in a population of patients with colorectal cancer.

The team's findings are published in the November issue of the Journal of Nuclear Medicine.

They reviewed PET and PET/CT images from 45 patients with known colorectal cancer, between June and November 2001.
The frequency of definite lesion characterization was increased by 30%.
Journal of Nuclear Medicine

Images were acquired with a PET/CT scanner, and 68Ge attenuation correction was applied.

The team scored lesion characterization on a 5-point scale: 0 = definitely benign, 1 = probably benign, 2 = equivocal, 3 = probably malignant, 4 = definitely malignant.

While they scored lesion location was scored on a 3-point scale. The team then assessed the presence or absence of a tumor using all available clinical, pathologic, and follow-up information.

The investigators determined that the frequency of equivocal and probable lesion characterization was reduced by 50% with PET/CT, compared with PET. The frequency of definite lesion characterization was increased by 30%.

The team was able to increase the number of definite tumor locations by 25% using PET/CT.

Furthermore, the correct staging increased from 78% to 89% with PET/CT on a patient-by-patient analysis.

Dr Christian Cohade's team concluded, "PET/CT imaging increases the accuracy and certainty of locating lesions in colorectal cancer".

"More definitely normal and definitely abnormal lesions (and fewer probable and equivocal lesions) were identified with PET/CT than with PET alone".

"Staging and restaging accuracy improved from 78% to 89%".

J Nuclear Med 2003; 44(11): 1797-1803
10 November 2003

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