In this study, investigators compared 18F-FDG PET and PET/CT in a population of patients with colorectal cancer.
The team's findings are published in the November issue of the Journal of Nuclear Medicine.
They reviewed PET and PET/CT images from 45 patients with known colorectal cancer, between June and November 2001.
|The frequency of definite lesion characterization was increased by 30%.|
|Journal of Nuclear Medicine|
Images were acquired with a PET/CT scanner, and 68Ge attenuation correction was applied.
The team scored lesion characterization on a 5-point scale: 0 = definitely benign, 1 = probably benign, 2 = equivocal, 3 = probably malignant, 4 = definitely malignant.
While they scored lesion location was scored on a 3-point scale.
The team then assessed the presence or absence of a tumor using all available clinical, pathologic, and follow-up information.
The investigators determined that the frequency of equivocal and probable lesion characterization was reduced by 50% with PET/CT, compared with PET. The frequency of definite lesion characterization was increased by 30%.
The team was able to increase the number of definite tumor locations by 25% using PET/CT.
Furthermore, the correct staging increased from 78% to 89% with PET/CT on a patient-by-patient analysis.
Dr Christian Cohade's team concluded, "PET/CT imaging increases the accuracy and certainty of locating lesions in colorectal cancer".
"More definitely normal and definitely abnormal lesions (and fewer probable and equivocal lesions) were identified with PET/CT than with PET alone".
"Staging and restaging accuracy improved from 78% to 89%".