Laminin and collagen IV may be extracellular matrix serum markers.
In this study, researchers from Greece measured serum concentrations of laminin and collagen IV in 170 patients with ulcerative colitis (UC) and Crohn’s disease (CD).
The team compared these measurements with 23 patients who had other causes of intestinal inflammation, and in 80 matched healthy controls.
The researchers found that laminin and collagen IV concentrations were correlated with disease activity, type, localization, and treatment.
Mean serum laminin concentrations were 281 ng/ml in patients with UC, 275.6 ng/ml in patients with CD, 192 ng/ml in healthy controls, and 198.5 ng/ml in inflammatory controls.
Mean serum collagen IV concentrations were 72.8 ng/ml in patients with UC, 71 ng/ml in patients with CD, 79.8 ng/ml in healthy controls, and 88.9 ng/ml in inflammatory controls.
The team determined that there was a significant difference among the 4 groups for both markers.
They identified a strong correlation between serum laminin, but not collagen IV, and disease activity in both diseases.
However, they did not find a significant association between the markers and disease localization or type.
Dr Koutroubakis's team concluded, "Serum concentrations of laminin are increased, whereas serum concentrations of collagen IV are decreased, in patients with inflammatory bowel disease".
"They may be useful surrogate markers for sustained inflammation and tissue remodeling".