In this study, investigators from the United States evaluated the differences in initial clinical presentation of young and older children with IBD. They also determined whether a positive family history of IBD was associated with the age of presentation.
The team reviewed the records of all patients with new diagnoses of Crohn's disease (CD) and ulcerative colitis (UC) who presented between 1996 and 1999.
Their initial evaluation included assessment of growth parameters and laboratory values. The team also determined the family history of IBD for each patient.
Throughout the study, the team assessed 153 patients. Of these, 82 had CD and 71 had UC.
|BMI at presentation was significantly lower in Crohn's patients.|
|Journal of Pediatric Gastroenterology and Nutrition|
The investigators found that children with CD had a higher sedimentation rate and platelet count, compared to children diagnosed with UC. In addition, CD patients had a lower mean hemoglobin concentration and serum albumin.
Body mass index at presentation was significantly lower in CD patients.
The team found that CD patients younger than 11 years had a higher mean platelet count than older patients.
They also found that 42% of younger patients with CD had a positive family history of IBD.
Dr Toba Weinstein's team concluded, "Except for higher platelet counts, a lower BMI, and a higher frequency of positive family history in young children with CD, there were no significant differences in the presentation of young children with IBD compared with older children".