A hypercoagulable state can occur in patients with inflammatory bowel disease.
In this study, investigators from Portugal determined the frequency of thrombophilic abnormalities in patients with Crohn's disease or ulcerative colitis.
The team assessed 116 patients with ulcerative colitis or Crohn's disease), as well as 141 asymptomatic blood donors was carried out.
They evaluated prothrombotic variables and genetic abnormalities.
|The frequency of 2 or more abnormalities was related to disease activity in Crohn's disease.|
|European Journal of Gastroenterology and Hepatology|
The research team found that the prevalence of single prothrombotic abnormalities in inflammatory bowel disease patients was higher than in the reference population.
Furthermore, the allelic frequency of genetic polymorphisms, for MTHFR C677T, ACE Del and PAI-1 4G, was higher in the IBD patients than the controls.
The team also determined that the prevalence of combined thrombophilic abnormalities in IBD patients was also higher than in the controls.
The differences were not found to be related to age or gender, but in Crohn's disease the frequency of 2 or more abnormalities was related to disease activity.
Dr Fernando Magro's team concludced, "Higher prevalences of single and combined thrombophilic defects were found in inflammatory bowel disease patients".