Restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) are the surgical treatments of choice for ulcerative colitis (UC).
However, the IPAA is sometimes complicated with pouchitis.
In this study, doctors aimed to evaluate the cumulative risk and risk factors for developing pouchitis in Japanese patients with UC undergoing IPAA.
The team retrospectively reviewed 58 patients for the presence of pouchitis, gender, age of onset, history of smoking, presence of extraintestinal manifestations (EIMs) and type of operation.
The diagnosis of pouchitis was based on the pouchitis disease activity index.
|The 5-year risk of pouchitis was 48% in patients with extraintestinal manifestations.|
|Scandinavian Journal of Gastroenterology|
The team calculated the cumulative risk and identified risk factors for developing pouchitis.
The doctors determined that the cumulative risks for developing pouchitis at 1 and 5 years were 9% and 14%, respectively.
However, they calculated that the risk of pouchitis at 5 years was 48% in patients with extraintestinal manifestations, compared to 5% in those without.
The team's analyses determined that the presence of extraintestinal manifestations was a significant risk factor for the development of pouchitis.
Dr Hata's team concluded, "The presence of extraintestinal manifestations is a significant risk factor for the development of pouchitis in Japanese patients with UC undergoing IPAA".