In this study, investigators from the United States determined the rate of recurrent primary biliary cirrhosis (PBC) after orthotopic liver transplantation (OLT). The team also evaluated the histologic progression of recurrent PBC over time.
The team established strict criteria for PBC recurrence as the presence of a florid duct lesion or destructive lymphocytic cholangitis within a dense portal infiltrate.
The team included 100 patients who met their criteria for the PBC study group, and 35 who met criteria for the control group.
|2 of 17 patients progressed to septal fibrosis.|
The strict histologic criteria for recurrent PBC were observed in 17% study patients.
The mean follow-up for the PBC group was 4.7 years, and the mean time to recurrence was 3.7 years.
In those in the recurrent PBC group, 2 of 17 patients progressed to septal fibrosis.
The team did not observe any florid duct lesions, destructive lymphocytic cholangitis, or septal fibrosis in the control group.
Dr Pamela Sylvestre's team concluded, "Based on strict criteria, a conservative histologic estimate of the rate of recurrent PBC is 17% during a mean of 4.7 years of follow-up.
"When criteria for histologic recurrence are expanded to include moderate lymphocytic cholangitis with lymphoplasmacytic portal infiltrate, the recurrence rate of PBC is estimated as 26%".