The performance of sphincter of Oddi manometry at ERCP is technically difficult. Patients must be well sedated.
Droperidol may be administered when adequate sedation cannot be achieved with benzodiazepine and meperidine.
In this study, physicians from Indiana, USA, examined the effects of droperidol on the biliary and pancreatic sphincters.
The team prospectively evaluated 31 patients by sphincter of Oddi manometry in the conventional retrograde fashion.
Manometry was initially performed with intravenous administration of diazepam alone, diazepam plus meperidine or midazolam plus meperidine.
Manometry was then repeated 5 minutes after droperidol was administered.
|42% of manometry tracings were qualitatively better after droperidol.|
The physicians found that the basal pressure of the biliary sphincter and the pancreatic sphincter were not significantly altered by droperidol.
The team observed concordance between the basal sphincter pressure before and after droperidol in 97% of patients.
Droperidol also did not lead to a difference in phasic wave amplitude, duration, or frequency.
The team determined that 42% of manometry tracings were qualitatively better after droperidol compared with 7% before droperidol administration.
Dr Evan Fogel's team concluded, "Droperidol does not significantly affect sphincter of Oddi manometric parameters".
"It appears that it can be added to the armamentarium of agents needed for performance of sphincter of Oddi manometry".
"However, further study is needed to determine whether recent safety concerns with droperidol use are valid".