In this study, a team of investigators from the United States determined whether increased body mass index (BMI) was associated with cirrhosis-related death or hospitalization.
The team evaluated 11,465 individuals, aged between 25 and 74 years, without evidence of cirrhosis. These subjects were followed-up for a mean of 12.9 years.
Participants were grouped using BMI into normal-weight (BMI <25 kg/m2), overweight (BMI 25 to <30 kg/m2), and obese categories (BMI 30 kg/m2).
The investigative team found that cirrhosis resulted in death or hospitalization of 89 participants during 150,233 person-years of follow-up.
|Cirrhosis-related death or hospitalization was more common in obese and overweight subjects.|
They determined that cirrhosis-related deaths or hospitalizations were more common in obese and overweight subjects, when compared with normal weight subjects.
Furthermore, in subjects who did not consume alcohol, the team identified a strong association between obesity or overweight and cirrhosis-related death or hospitalization.
This association was weaker in study participants who consumed up to 0.3 alcoholic drinks per day, and was absent in those who consumed more than 0.3 alcoholic drinks per day.
Dr George Ioannou's team concluded, "Obesity appears to be a risk factor for cirrhosis-related death or hospitalization among persons who consume little or no alcohol".