Researchers have found that a prognostic index including age, Pugh score, ascites and serum creatinine is valuable in patients with Budd-Chiari syndrome. Furthermore, surgical portosystemic shunt does not improve survival.
In this study, physicians from France sought to validate these findings in an independent sample. They also aimed to develop a classification according to the presence of features of acute injury (type I), chronic lesions (type II), or both of them (type III).
The team performed a multivariate Cox model survival analysis on 69 new patients and 54 patients from their previous study.
|Type III patients had the poorest outcome.|
|Journal of Hepatology|
The physicians determined that their previous index had a significant prognostic value. They found that this prognostic value was further improved by taking into account type III Budd-Chiari syndrome. This type was associated with the poorest outcome.
Furthermore, the team determined that surgical shunting had no significant impact on survival.
Dr Philippe Langlet's team concluded, "The prognosis of Budd-Chiari syndrome can be based on age, Pugh score, ascites, serum creatinine and the presence of features indicating acute injury superimposed on chronic lesions (type III form)".
"The idea that surgical shunting has no significant impact on survival is reinforced by these findings".