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 24 February 2018

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News

Operative morbidity of living liver donors in Japan

In contrast to western countries, no perioperative mortality has been recorded in living liver donors in Japan, find researchers in the latest issue of the Lancet.

News image

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Deaths of living liver donors have been reported in western countries. However, the morbidity and mortality of living liver donors in Japan has not been studied.

In this study, a team of physicians reviewed the operative morbidity and mortality of these donors.

They studied 1853 donors of 1852 living liver transplants at 46 centers. These donors were registered in the database of the Japanese Liver Transplantation Society.

Overall, the team analyzed the data of 1841 donors for 8 donor-related factors of morbidity and mortality.

Complications were significantly higher in right lobe donors.
Lancet

No perioperative mortality was recorded between the inception of the liver transplantation program in 1989 and 2002.

The researchers found that there were 244 postoperative complications were reported in 228 donors.

They determined that complications were significantly higher in right lobe donors, compared to those involving the lateral segment, and the left lobe.

Furthermore, postoperative hospital stay was significantly longer in right lobe donors.

The doctors found that re-operation, related to donor hepatectomy, occurred in 23 donors.

Dr Koji Umeshita's team concluded, "By contrast with western countries, no perioperative mortality was recorded in living liver donors in Japan".

"However, a proportion of these donors developed serious complications".

"This morbidity should be reduced to maintain zero mortality in living liver donors".

Lancet 2003; 362: 687-90
05 September 2003

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