Whether the outcome of liver retransplantation is dependent on the indication for retransplantation or the cause of liver disease is unknown.
In this study, physicians from Baltimore, Maryland, compared the outcome of retransplantation in adults with that of primary liver transplantation (PLT). They assessed whether the outcome of retransplantation was dependent on its indication.
The research team used data from the United Network for Organ Sharing from 1988 to 2001.
|Hepatitis C virus infection is an independent predictor of mortality after liver retransplantation.|
Overall, the team identified 34,267 patients who met their inclusion criteria.
Of these, 761 patients underwent liver retransplantation for primary graft nonfunction (PGNF) (group 1), 3428 patients underwent retransplantation for other reasons (group 2), and 30,078 patients underwent PLT (group 3).
The researchers identified a greater incidence of PGNF and regrafting in the retransplant groups when compared with the PLT group.
In addition, analysis showed significantly lower short- and long-term patient and graft survival in the retransplant groups compared with the PLT group.
Furthermore, the team found that patients in group 1 had lower patient and graft survival compared with group 2.
However, when data was analyzed using Cox regression they found that graft survival not patient survival was lower in group 1.
The team also found that patients with hepatitis C virus (HCV) infection who underwent retransplantation had lower patient and graft survival compared with those without HCV infection.
HCV was identified as an independent predictor of mortality after liver retransplantation.
Dr Hwan Yoo's team concluded, "Retransplantation was associated with a greater rate of complications and lower patient and graft survival compared with PLT".
"Retransplantation for PGNF and HCV infection was associated with lower patient and graft survival compared with retransplantation for other causes".