The relationship between Helicobacter pylori infection and its treatment and gastro-oesophageal reflux disease (GERD) is controversial.
A team from the USA and Italy conducted a meta-analysis of existing research to clarify the link between between H. pylori and GERD.
The latest study also aimed to establish whether anti-H. pylori treatment leads to de novo GERD or exacerbation of existing GERD.
The research team calculated a pooled odds ratio for the association between H. pylori negative status and GERD of 1.34.
| The significance of the association between GERD and anti-H. pylori treatment appears to have been inflated by the effect of single trials and by geographical variations.
|Alimentary Pharmacology and Therapeutics|
The pooled odds ratios for the association of anti-H. pylori therapy with de novo GERD and exacerbation of GERD were 3.25 and 2.39 respectively.
The meta-analysis revealed a stronger association between anti-H. pylori treatment and GERD in Asian studies compared to those conducted in North America or Europe.