Various factors regarding the biological state of tumors or the nutritional state of patients have been individually reported to correlate with the prognosis of esophageal cancer.
Research published in the August issue of Annals of Surgery identifies the significant host and tumor-related factors for predicting the prognosis of esophageal cancer.
| PIEC demonstrated a good stratification value for prognosis .|
|Annals of Surgery|
The authors of the study analyzed a number of clinicopathological factors in 356 consecutive patients with surgical treatment for esophageal cancer.
Significant differences in survival were found for sex, serum C-reactive protein, lymphocyte number, body weight change, serum albumin l, serum squamous cell-related antigen, and clinical Tumor Node Metastasis (TNM) staging.
The research team devised a new prognostic index for esophageal cancer (PIEC) by combining serum C-reactive protein elevation, body weight loss, and clinical TNM staging III and IV into a single score.
PIEC was shown to be superior to the conventional clinical TNM staging in providing an informative pre-treatment prognosis for esophageal cancer patients.