In this study, physicians from the Netherlands examined recent time trends in incidence and outcome of upper GI bleeding.
The team evaluated prospective data from all patients who presented with acute upper GI bleeding within a defined geographical area in 1993/1994 and 2000.
The researchers found that the incidence of upper GI bleeding decreased from 61.7/100,000 in 1993/94 to 47.7/100,000 individuals per year in 2000. This was a 23% decrease in incidence once data was adjusted for age.
The team determined that the incidence was higher in older patients.
|Ulcer bleeding was the most frequent cause of bleeding.|
|American Journal of Gastroenterology|
Rebleeding and mortality did not differ between the 2 time periods.
The physicians established that ulcer bleeding was the most frequent cause of bleeding.
Incidence remained stable for both duodenal and gastric ulcer bleeding.
They found that a half of all patients with peptic ulcer bleeding were using nonsteroidal anti-inflammatory drugs or aspirin.
They also found, that in patients with ulcer bleeding, rebleeding and mortality did not differ between the 2 time periods.
The team identified increasing age, presence of severe and life-threatening comorbidity, and rebleeding as factors associated with higher mortality.
Dr van Leerdam's team concluded, "Between 1993/1994 and 2000, among patients with acute upper GI bleeding, the incidence rate of upper GI bleeding significantly decreased, but no improvement was seen in the risk of rebleeding or mortality in these patients".
"The incidence rate of ulcer bleeding remained stable".
"Prevention of ulcer bleeding is important".