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 25 November 2017

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News

Bone mineral density in patients with Crohn's disease

Low bone mineral density occurs frequently in Crohn's disease, but a decline in bone mineral density over time does not, despite continued corticosteroid use, find researchers in the July issue of Digestive Diseases and Sciences.

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Osteoporosis frequently occurs in patients with Crohn's disease.

In this study, researchers from the Netherlands retrospectively evaluated patients' rate of bone loss over time, and the influence of disease-related factors on bone loss.

They enrolled 29 patients (8 male) in the study.

Subjects underwent repeated bone mineral density (BMD) assessments. The mean interval between assessments was 41 months.

The BMD, measured by dual energy x-ray absoptiometry, was expressed in grams per square centimeter, and as sex- and age-matched Z score.

During the course of the study 27 patients used corticosteroids (mean dose 8.6 g), and 21 patients used some form of bone protective medication.

Initial Z scores were significantly below zero.
Digestive Diseases and Sciences

The researchers found that initial Z scores, at a mean age of 41 years, were significantly below zero.

However, the team did not identify a change in absolute BMD over time.

During the study, the research team observed an increase in body weight and a decrease in erythrocyte sedimentation rate (ESR).

Multilinear regression analysis found that a change in ESR was an independent predictor of change in femoral Z score.

Dr De Jong's team concluded, "Low BMD is frequent in Crohn's disease, but decline of BMD over time was not found, despite ongoing use of corticosteroids".

Dig Dis Sci 2003; 48(7): 1355-9
08 July 2003

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