In this study, researchers from Italy estimated the risk of acute hepatotoxicity associated with nimesulide, compared with other non-steroidal anti-inflammatory drugs (NSAIDs).
The team performed a retrospective cohort and nested case-control study.
|Current NSAID use was associated with a 1.4 increased risk of hepatopathy.|
|British Medical Journal|
They evaluated 400,000 current, recent, and past users of NSAIDs, between 1997 and
The team measured admission to hospital for acute non-viral hepatitis, incidence of all hepatopathies, and liver injury among users of nimesulide and other NSAIDs.
The researchers found that current use of NSAIDs was associated with a 1.4 increased risk of hepatopathy, compared with past use.
They determined that the rate ratio was 1.3 for all hepatopathies, and 1.9 for more severe liver injury, in current users of nimesulide
Dr Giuseppe Traversa's team concluded, "The risk of liver injury in patients taking nimesulide and other non-steroidal anti-inflammatory drugs is small".