Closure of the abdomen in patients who have undergone intestinal transplantation can be extremely difficult.
In this study, researchers from Miami, Florida, describe their experience with abdominal wall allotransplantation to facilitate abdominal closure.
The team performed 9 cadaveric abdominal wall composite allograft transplants in 8 patients.
|Of the 8 patients in the study, 6 patients survived.|
They based the graft's blood supply on the inferior epigastric vessels left in continuity with the donor femoral and iliac vessels.
The researchers took skin biopsies at random intervals, and when they suspected rejection.
They also monitored vessel patency using Doppler ultrasound.
Of the 8 patients, 6 patients survived. Of these, 5 had intact, viable abdominal wall grafts.
The researchers found that 2 patients had mild episodes of acute rejection of the skin of the abdominal wall. This was resolved with corticosteroid therapy.
The team did not identify any clinically apparent graft-versus-host disease.
Dr David Levi's team concluded, "Transplantation of an abdominal wall composite allograft can facilitate reconstruction and closure of the abdominal compartment in intestinal transplant recipients with complex abdominal wall defects".