The correlation between age and the outcome following an operation for colorectal cancer (CRC) has not yet been determined.
In this study, researchers from Japan evaluated the appropriate operation for elderly patients with CRC, based upon the assessment of preoperative risk factors.
The team assessed 70 patients, over 80 years old, with Dukes' stage B or C. They matched these with 66 patients, aged between 50 and 69 years.
|Preoperative condition was poorer in the older patients.|
The researchers compared the preoperative condition, grade of surgical intervention, perioperative activities of daily life (ADL), and survival rates of the 2 groups.
They found that preoperative condition was poorer, and the frequency of patients who underwent a deterioration in ADL during the perioperative period was higher in the older group of patients.
Furthermore, the older group showed significantly lower peripheral lymphocyte counts in patients with major postoperative complications. The team also found that the 1% forced expiratory volume (FEV1%) was significantly lower in patients with a deterioration in ADL.
The researchers found that a low grade of surgical intervention was related to a poor prognosis for rectal cancer in the aged group.
Dr Yasuyuki Miyakura's team concluded, "The indications for operation in elderly CRC patients should be determined based upon an appropriate assessment of preoperative conditions, such as the lymphocyte count and FEV1%".