In this study, researchers from the United States assessed whether antimicrobial resistance in pathogens and outcome in patients with spontaneous bacterial peritonitis (SBP) has changed over time.
The team evaluated 61 consecutive cases of SBP in patients with end-stage liver disease who were undergoing evaluation for liver transplantation.
They divided patients into 2 cohorts: 1991 to 1995, and 1996 to 2001.
|30-day mortality = 26%.|
|Clinical Microbiology and Infection|
The researchers found that 19% of all bacteria were multiple-antibiotic resistant.
Furthermore, they determined that multiple-antibiotic resistance in bacteria increased from 8% in the earlier cohort to 39% in the later cohort.
They found that mortality at 30 days was 26%. There was no difference in mortality between the 2 time periods.
The team established that mortality was significantly higher in patients with multiple-antibiotic-resistant bacteria than in those with other bacteria.
However, they also found that the Child-Pugh score, and renal failure were the only independently significant predictors of mortality in patients with SBP.
Dr Singh's team concluded, "Mortality in patients with end-stage liver disease who developed SBP has remained unchanged over the last decade".
"Although multiple-antibiotic resistance in bacteria causing SBP has increased over time, the severity of hepatic and renal dysfunction were the predominant determinants of outcome in these patients".