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 23 November 2017

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News

Polymer-coated versus polyethylene stents in distal malignant biliary obstruction

Hydrophilic polymer-coated polyurethane stents do not prolong the patency period of biliary stents, finds a research team in the June issue of Endoscopy.

News image

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Hydrophilic polymer-coated polyurethane (HPCP) stents have a low friction coefficient and a hydrophilic layer. This is thought to reduce biofilm formation and increase the period of stent patency.

In this study, researchers from the Netherlands compared patency rates of these new stents, with standard Amsterdam-type polyethylene (PE) stents.

Median stent patency period:
- Polymer-coated = 77 days
- Polyethylene = 105 days
Endoscopy

The team evaluated 100 patients with unresectable distal malignant bile duct strictures, without a previous drainage procedure.

Patients were randomly assigned to receive either a HPCP stent or a PE stent. Stent diameter, length, and stent design were similar.

Overall, the team excluded 9 patients, while 44 patients received an HPCP stent and 47 patients a PE stent.

Diagnoses included carcinoma of the pancreas (n = 78), papilla (n = 1), bile duct (n = 10), and metastases (n = 2).

Stent insertion was successful in all patients.

The researchers found that stent dysfunction occurred in 27 of the HPCP stents and 20 of the PE stents.

They determined that median stent patency periods were 77 days for HPCP stents and 105 days for PE stents. The patency period was significantly longer for the PE stent.

The team also found that early complications occurred in 4 patients; 1 in the HPCP group and 3 in the PE group.

Dr van Berkel's team concluded, "Hydrophilic polymer-coated polyurethane stents do not prolong the patency period of biliary stents".

"In fact, the current standard treatment using polyethylene stents in patients with distal malignant biliary obstruction showed a significantly longer patency period".

Endoscopy 2003; 478-82
05 June 2003

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