The prognosis of Borrmann type 4 gastric cancer remains poor. In addition, the relative contributions of genetic and nongenetic factors to type 4 gastric cancer are unclear.
The study of family history and spousal history of cancer may play an important role in the assessment of causation of this severe gastric cancer.
In this study, researchers from Japan assessed 1118 consecutive patients with histologically confirmed gastric cancer, including 113 with type 4 carcinoma. Patients were admitted to the National Cancer Center Hospital between 1995 and 1997.
The research team obtained data on the type of carcinoma, as well as the family history of cancer in first-degree relatives and spouses of the probands, from medical records.
|Maternal history was associated with a fourfold risk of daughters type 4 carcinoma.|
Family history and spousal history of cancer were compared between type 4 and other types of gastric cancer.
The researchers found that paternal history had no association with type 4 carcinoma compared with other types. However, maternal history was associated with a fourfold risk of daughters type 4 carcinoma, but not sons.
Furthermore, among probands whose wives had a history of gastric cancer, the risks of type 4 gastric cancer were significantly increased, to as high as 13-fold.
However, husbands history had no relationship with wives type 4 carcinoma.
No relationship between type 4 carcinoma and family history or spousal history of other cancers was observed.
Dr Ying Liu's team concluded, "Environmental factors may have a key effect in causing type 4 carcinoma".
"Findings may be valuable for identifying subjects at high risk of such malignant gastric cancer as Borrmann type 4".