In this study, researchers from the United States assessed whether aprotinin use during adult liver transplantation resulted in an improvement in hemodynamic stability.
The research team reviewed data collected during a prospective, randomized, double-blind trial.
They assessed 63 adult patients undergoing orthotopic liver transplantation (OLT), at a tertiary referral institution.
- aprotinin group = 3%
- placebo = 20%
|Journal of Clinical Anesthesia|
The team randomized patients to receive either aprotinin for the duration of the surgery, or a placebo infusion.
They measured hemodynamic parameters including mean systemic blood pressure, cardiac output, systemic vascular resistance, mean pulmonary artery (PA) pressure, and PA occlusion pressure. These were compared at set time points during the procedure.
The use of vasoactive medications during and after the reperfusion period was also compared.
The research team found that there were no significant differences in any of the measured hemodynamic parameters at any time point.
However, they found that vasoactive infusions were used in 3% of patients in the aprotinin group and in 20% of patients in the control group.
Bolus doses of pressor medications during the recirculation period did not differ between groups.
Drs James Findlay and Ronald Kufner concluded, "Aprotinin infusion during adult liver transplantation results in less requirement for vasoactive intervention".