Orlistat treatment of obesity results in a poor long-term weight loss in approximately 30% of patients.
In this study, researchers from Switzerland examined total energy and macronutrient intake to assess the effect of a change in eating habits on weight loss.
The team assessed 62 patients who consumed a hypocaloric diet, together with orlistat, for 72 weeks. Patients consumed a maximal fat allowance of 30% of the energy intake.
Patients kept food diaries at regular intervals.
|All groups increased their carbohydrate consumption.|
|Alimentary Pharmacology and Therapeutics|
Of the 62 patients, 56 completed the study. They lost a mean of 8.5 kg.
The patient's energy intake was approximately 1500 kcal per day for the entire study period.
The research team found that in 3 weight-loss subgroups (group 1 = < 5%, group 2 = between 5 and 10%, group 3 = > 10%), fat intake was within the recommended range during the first 6 months. However, after 6 months this was only the case for group 3.
In addition, all groups increased their carbohydrate consumption. The greatest increase was in group 1, which could account for the rapid regain of initially lost body weight in this group.
Dr Ullrich's team concluded, "At the beginning of a weight management program in conjunction with orlistat, a low fat intake is advised for an efficient reduction in body weight".
"Subsequently, in patients with poor long-term weight loss, dietary recommendations must also consider carbohydrate restriction to ensure an adequate hypocaloric diet".