In this study, researchers determined the outcome of resections for local recurrence of colorectal carcinoma in the presence of distant (M1) disease.
Their findings are reported in the latest issue of the Annals of Surgical Oncology.
The research team identified patients who underwent resection of local recurrence in the presence of potentially resectable M1 disease from a database.
|Median survival of all patients was 14.5 months.|
|Annals of Surgical Oncology|
They determined outcome in these patients by chart review.
In total, 42 patients (mean age 60 years) underwent complete gross resection of their local recurrence in the presence of M1 disease.
Of these 42 patients, 13 underwent synchronous M1 resections to render them free of gross disease (R0).
Of the 29 patients with residual disease (R1), 9 underwent staged M1 resection. Overall, 22 of 42 were rendered R0 by surgery.
The team found that the median survival of all patients was 14.5 months, that of patients rendered R0 was 23 months. This compared with median survival of 7 months for patients with R1 status.
Achieving R0 status by synchronous or staged resection was the only factor which predicted survival.
Dr Hartley's team concluded, "The presence of M1 disease per se should not preclude resection of local recurrence, although case selection is problematic".