Researchers from the Netherlands and England investigated the effects of motilin on the proximal stomach in patients with functional dyspepsia (FD) and healthy volunteers.
The team assessed 8 healthy volunteers and 12 patients with FD, who were infused with synthetic motilin or placebo.
They measured proximal gastric volume with a barostat, at constant pressure and during isobaric distensions.
Abdominal symptoms were scored using visual analog scales.
| Patients were more nauseous with motilin than with placebo.|
|AJP Gastrointestinal and Liver Physiology|
In addition, the team measured plasma motilin concentrations using radioimmunoassay.
The researchers found that motilin concentrations and baseline gastric volumes were similar for both patients and healthy volunteers.
However, motilin reduced gastric volume by 112 ml in patients and by 96 ml in healthy volunteers, compared with placebo.
In patients, motilin decreased compliance by 76 ml/mmHg compared with placebo. This response was similar in volunteers.
Patients were more nauseous with motilin than with placebo, whereas healthy volunteers did not experience nausea.
Dr Ingrid Kamerling's team concluded, "In a fasted condition, FD patients have a similar proximal gastric motor response to motilin as healthy volunteers, but experience an exaggerated sensation of nausea".