GI endoscopy without general anesthesia causes a hyperperistaltic state in the stomach. This frequently necessitates the use of antispasmodic agents, such as hyoscine-N-butylbromide.
Peppermint oil is harmless and acts locally to inhibit GI smooth muscle contraction.
In this study, researchers from Tokyo, Japan, compared the antispasmodic effects of hyoscine-N-butylbromide and a placebo solution. They also compared the effects of a placebo solution with a peppermint oil solution.
The team used a randomized double-blind, double-dummy, controlled trial, which included 100 patients
|No significant side effects were associated with peppermint oil.|
The team defined the percent change in diameter of the pyloric ring before and after as the opening ratio. In addition, the percent change in diameter between the maximally and minimally opened pyloric ring states was defined as the contraction ratio.
The team also measured the time until disappearance of the contraction ring(s) in the gastric antrum, and the side effects of the drugs.
The researchers found that the opening ratio was significantly higher in the peppermint oil group than in the hyoscine-N-butylbromide group.
In addition, the contraction ratio after peppermint oil administration was significantly lower than that after hyoscine-N-butylbromide injection.
The team also determined that the time required for disappearance of the antral contraction ring(s) was shorter in the peppermint oil group than in the hyoscine-N-butylbromide group.
Furthermore, no significant side effects were associated with peppermint oil. However, hyoscine-N-butylbromide injection produced side effects such as dry mouth, blurred vision, and urinary retention.
Dr Naoki Hiki's team concluded, "Peppermint oil solution administered intraluminally can be used as an antispasmodic agent with superior efficacy and fewer side effects than hyoscine-N-butylbromide administered by intramuscular injection during upper endoscopy".