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 21 November 2017

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News

Mortality caused by inflammatory bowel disease

Younger patients and those within the first year of diagnosis account for a significant proportion of deaths due to IBD, finds a research team from Wales.

News image

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Previous studies have been either regional, if population based, or entirely based on statistics from the Registrar General’s office.

In this study, researchers ascertained the non-cancer mortality from inflammatory bowel disease (IBD), via a notification system throughout the United Kingdom, from 2000 to 2001.

The team compared these data with that from the Office for National Statistics (ONS).

The team’s findings are reported at this week’s BSG meeting in Birmingham, England.

All deaths in patients with IBD were notified to the BSG central audit office.

In addition, the research team gained further details and death certificate diagnosis from the notifying clinician.

They performed subgroup analysis according to diagnosis, age, sex, cause of death, duration, site, extent, and operative mortality.

24% of patients died within a year of diagnosis.
BSG

These data were then compared with that from the ONS in England and Wales, Scotland and Northern Ireland.

The research team found that 132 patients were recorded as having died due to IBD during this period. Of these 108 were under 75 years old.

The team found that 61 patients had Crohn’s disease, 44 had ulcerative colitis (UC) and 3 had indeterminate colitis.

The team determined that 24% of patients died within a year of diagnosis, 33% died within 2 years of diagnosis, while 7% had death attributed to medical therapy.

They also found that 47% had surgery prior to death. The median time to surgery after death was 7 days.

When analyzed according to immediate cause of death, 21% of patients had septicemia, 17% colonic perforation, 8% multi-organ failure, 7% thromboembolic events, and 7% pneumonia.

Overall, the team determined that patients under the age of 35 years accounted for 25% of all deaths.

During the same period, the team found that the ONS reported 128 deaths due to UC and 240 to Crohn’s disease. This includes cancer-related IBD mortality.

Dr Dolwani’s team concluded, “Younger patients and those within the first year from diagnosis, as well as those undergoing surgery, account for a significant proportion of all deaths due to IBD in the UK”.

BSG
25 March 2003

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