There is controversy as to whether Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) interact to cause peptic ulcers.
In this study, researchers from Hong Kong, China, assessed whether H. pylori eradication in patients on long-term NSAID therapy prevented the development of ulcers.
The research team included patients infected with H. pylori whilst receiving long-term NSAID drug therapy, but who had no ulcers at baseline endoscopy.
|Peptic ulcer development:|
- triple therapy = 7%
- placebo = 9%
|Alimentary Pharmacology and Therapeutics|
Patients were randomized to receive either triple antibiotic therapy or placebo for 2 weeks.
NSAIDs were continued throughout the study period.
The team performed an endoscopy 12 weeks after the end of treatment.
They compared the development of ulcers between the 2 groups.
The team found that endoscopy at 12 weeks revealed peptic ulcer development in 7% of the patients who received triple therapy and in 9% of those who received placebo.
The team also found no significant difference in the development of ulcers in patients with persistent H. pylori infection (9%) and those with successful eradication (8%).
Dr Lai’s team concluded, “The eradication of H. pylori in patients receiving long-term treatment with NSAIDs did not prevent ulcer development”.
“However, because the rate of ulcer development was low, a study with a larger sample size is required to confirm this finding.”