Patients have reported that the prophylactic consumption of a proton pump inhibitor minimizes GI symptoms provoked by late-night food and alcohol consumption. However, the efficacy of this practice has not been studied.
In this study, researchers from Ireland performed a randomized, double-blind, placebo-controlled trial of a single dose of lansoprazole (30 mg). This was taken prior to a large meal and alcohol consumption.
The team recruited 56 study subjects (37 male, 19 female, mean age 38 years) from local primary care and hospital physicians.
Each participant completed a questionnaire before and after the meal.
|No significant difference found between the lansoprazole and placebo group.|
|Alimentary Pharmacology and Therapeutics|
Approximately 90 minutes prior to the meal, the study participants were given either 30 mg lansoprazole or placebo.
The team dispensed bar tokens to ensure accurate quantification of alcohol consumption.
The researchers found that 40% of subjects reported significant reflux symptoms. Overall, there was no significant difference between the lansoprazole and placebo group.
They determined that post-prandial reflux was more frequent in those consuming >15 units of alcohol, compared with those consuming <15 units.
However, the team found that lansoprazole use in those who consumed >15 units of alcohol was associated with a lower rate of heartburn (33%) compared with placebo (73%).
Dr O'Leary's team concluded, "A single dose of a proton pump inhibitor prior to indulgence was only associated with reduced heartburn in those consuming >15 units of alcohol."