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News

Trends in the subsite and morphology of esophageal and gastric cancer

Increase in adenocarcinoma of the gastric cardia is probably real, but interpretation is limited by the proportion of cancers without specified subsites or morphologies, find researchers in the latest issue of Alimentary Pharmacology and Therapeutics.

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The incidence of adenocarcinoma of the esophagus and gastric cardia has increased in many countries.

Esophageal adenocarcinoma increased from 1.5 to 7.0 per 100,000 men between 1971 and 1998.
Alimentary Pharmacology and Therapeutics

In this study, researchers from England used cancer registry data, from 1971 to 1998, to describe the trends in the subsite and morphology of esophageal and gastric cancer.

The research team calculated the overall age-standardized incidence in each year. They also calculated the age-standardized incidence by subsite, by morphology, and by subsite and morphology. In addition, the team assessed the ratio of the rates in men and women in 1971 and 1998.

The team found that the incidence of esophageal adenocarcinoma increased from 1.5 to 7.0 per 100,000 men and from 0.4 to 1.5 per 100,000 women.

They also found that the incidence of cancer at the cardia also increased, from 2.0 to 5.4 per 100,000 men and from 0.6 to 1.4 per 100,000 women. However, the incidence of gastric cancer without a specified subsite decreased markedly from 21.3 to 9.3 per 100,000 men and from 10.7 to 4.2 per 100,000 women.

Dr Newnham's team concluded, "Although some of the increase in the incidence of adenocarcinoma of the gastric cardia is probably real, this interpretation is limited by the proportion of cancers without specified subsites or morphologies."

Aliment Pharmacol Ther 2003; 17(5): 665-76
17 March 2003

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