Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 26 February 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Severe hepatotoxicity during combination antiretroviral treatment

Liver damage may be caused by immune reconstitution and related exacerbation of viral hepatitis during antiretroviral therapy, find researchers in the March issue of the Journal of Acquired Immune Deficiency Syndromes.

News image

fiogf49gjkf04

In this study, researchers from Italy assessed incidence, risk factors, histology, and outcome of severe hepatotoxicity (SH) during antiretroviral treatment (ART).

The team included 755 HIV-seropositive patients prescribed new ART in the study.

Liver function tests were assessed at baseline, after 1 month, and every 4 months thereafter.

The team performed liver biopsies in the case of SH.

Liver damage was invariably observed in patients with chronic viral hepatitis.
Journal of Acquired Immune Deficiency Syndromes

The research team observed 26 cases of SH, with an incidence of 4% person-years. However, liver failure was rarely seen.

The team found that liver damage was invariably observed in patients with chronic viral hepatitis.

Liver histology showed exacerbation of viral hepatitis in all 16 patients for whom a liver biopsy was available at the time of SH.

They found a direct correlation between alanine aminotransferase increase and increase in CD4+ T-cell count in patients with SH.

Death occurred during follow-up in 7 of the 26 patients with SH. All showed liver failure and a baseline CD4+ count less than 200 cells/mm3.

In addition, the researchers observed relapse of SH following recommencement of ART, in 7 of 17 patients. However, 5 of these 7 patients did not show further SH relapse after treatment with interferon.

Dr Massimo Puoti’s team concluded, “This study provides estimates of SH and liver failure…where hepatitis C virus coinfection is highly prevalent and provides indications that liver damage may be caused by immune reconstitution and related exacerbation of viral hepatitis”.

“A strict follow-up for hepatotoxicity is mandatory when ART is initiated in patients with < 200 CD4+ T cells/mm3.”

“Antihepatitis pre- or comedication could be an effective preventive or curative measure.”

J Acquir Immune Defic Syndr 2003; 32(3): 259-67
12 March 2003

Go to top of page Email this page Email this page to a colleague

 24 February 2017 
High-dose Vitamin D3 in Crohn’s disease in remission
 24 February 2017 
Risk factors for hepatitis E infection
 24 February 2017 
Complications after ileocecal resection in Crohn’s
 23 February 2017 
Video games in covert hepatic encephalopathy
 23 February 2017 
Video games in covert hepatic encephalopathy
 23 February 2017 
Safer interval elective surgery for adults with Crohn's
 23 February 2017 
Quality of care for GERD 
 22 February 2017 
Predicting response to corticosteroids in severe alcoholic hepatitis
 22 February 2017 
Gluten exposure in celiac disease
 22 February 2017 
Confocal laser endomicroscopy for gastric cancer
 21 February 2017 
Anesthetics during outpatient gastroenterology procedures
 21 February 2017 
Cancer survival in Lynch syndrome 
 21 February 2017 
Motor peripheral nerve injury after colorectal surgery
 20 February 2017 
Concepts of cirrhotic coagulopathy
 20 February 2017 
Smoking at diagnosis and colon cancer survival
 20 February 2017 
Advanced neoplasms with low-risk adenomas
 17 February 2017 
Genetic mutations predict esophageal cancer
 17 February 2017 
Anesthesia services during outpatient gastroenterology procedures
 17 February 2017 
Genetic mutations predict esophageal cancer
 16 February 2017 
Anesthetist-directed sedation in endoscopic procedures
 16 February 2017 
Assisted reproduction in women with IBD 
 16 February 2017 
Hysterectomy and pelvic floor disorders
 15 February 2017 
Increasing screening of cirrhosis in hepatocellular carcinoma
 15 February 2017 
Metal stents for palliation in malignant biliary obstruction
 15 February 2017 
Hepatocellular carcinoma in the USA
 14 February 2017 
Preventive care in IBD 
 14 February 2017 
Infliximab dose for acute severe ulcerative colitis
 14 February 2017 
Pathologists agreement in the diagnosis of Barrett's
 13 February 2017 
H. pylori treatment guidelines
 13 February 2017 
Vasoactive drugs for hepatorenal syndrome type 1
 13 February 2017 
Pregnancy outcomes after endoscopy
 10 February 2017 
Primary ileocecal resection in pediatric Crohn's disease
 10 February 2017 
Non-adherence in end-stage liver disease
 10 February 2017 
Isolated colonic Crohn's disease
 09 February 2017 
Mucosal healing in ulcerative colitis
 09 February 2017 
NAFLD and coronary artery calcium score
 09 February 2017 
Prevalence of Hep D in chronic Hep B infection
 08 February 2017 
Rifaximin for small intestine bacterial overgrowth
 08 February 2017 
Risk prediction of interval cancers from inadequate colonoscopy quality
 08 February 2017 
Meta-analyses in gastroenterology and hepatology journals
 07 February 2017 
Chemoprevention in colon cancer
 07 February 2017 
Methotrexate intolerance in pediatric IBD 
 07 February 2017 
Untreated hepatocellular carcinoma in the USA
 06 February 2017 
Vitamin D levels and risk of relapse in ulcerative colitis
 06 February 2017 
Giardia in the USA
 06 February 2017 
Colorectal cancer risk in serrated polyposis syndrome
 03 February 2017 
Helicobacter and Campylobacter in IBD
 03 February 2017 
Mortality risk in elderly-onset IBD
 03 February 2017 
Management of chronic refractory pouchitis
 02 February 2017 
IBD-related research and publications
 02 February 2017 
TWEAK in IBD
 02 February 2017 
Clostridium difficile and colectomy risk in IBD
 01 February 2017 
Suboptimal bowel preparation in outpatient colonoscopy
 01 February 2017 
Fecal microbiota transplantation
 01 February 2017 
Socio-economic distribution of IBD 
 31 January 2017 
Gastroenterology fellowship
 31 January 2017 
Approach to Lynch syndrome
 31 January 2017 
Fat intake and ulcerative colitis risk
 30 January 2017 
Dietary risk of acute pancreatitis
 30 January 2017 
Care pathway for anemia in IBD 

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us