Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 28 March 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Severe hepatotoxicity during combination antiretroviral treatment

Liver damage may be caused by immune reconstitution and related exacerbation of viral hepatitis during antiretroviral therapy, find researchers in the March issue of the Journal of Acquired Immune Deficiency Syndromes.

News image

fiogf49gjkf04

In this study, researchers from Italy assessed incidence, risk factors, histology, and outcome of severe hepatotoxicity (SH) during antiretroviral treatment (ART).

The team included 755 HIV-seropositive patients prescribed new ART in the study.

Liver function tests were assessed at baseline, after 1 month, and every 4 months thereafter.

The team performed liver biopsies in the case of SH.

Liver damage was invariably observed in patients with chronic viral hepatitis.
Journal of Acquired Immune Deficiency Syndromes

The research team observed 26 cases of SH, with an incidence of 4% person-years. However, liver failure was rarely seen.

The team found that liver damage was invariably observed in patients with chronic viral hepatitis.

Liver histology showed exacerbation of viral hepatitis in all 16 patients for whom a liver biopsy was available at the time of SH.

They found a direct correlation between alanine aminotransferase increase and increase in CD4+ T-cell count in patients with SH.

Death occurred during follow-up in 7 of the 26 patients with SH. All showed liver failure and a baseline CD4+ count less than 200 cells/mm3.

In addition, the researchers observed relapse of SH following recommencement of ART, in 7 of 17 patients. However, 5 of these 7 patients did not show further SH relapse after treatment with interferon.

Dr Massimo Puoti’s team concluded, “This study provides estimates of SH and liver failure…where hepatitis C virus coinfection is highly prevalent and provides indications that liver damage may be caused by immune reconstitution and related exacerbation of viral hepatitis”.

“A strict follow-up for hepatotoxicity is mandatory when ART is initiated in patients with < 200 CD4+ T cells/mm3.”

“Antihepatitis pre- or comedication could be an effective preventive or curative measure.”

J Acquir Immune Defic Syndr 2003; 32(3): 259-67
12 March 2003

Go to top of page Email this page Email this page to a colleague

 29 March 2017 
Telemedicine in gastroenterology
 29 March 2017 
Red meat and pancreatic cancer risk
 29 March 2017 
Therapeutic goals in Crohn's and rheumatoid arthritis
 28 March 2017 
H. pylori infection in junior high school students
 28 March 2017 
BMI and laporoscopic colorectal surgery
 28 March 2017 
Surgery for gallbladder cancer
 27 March 2017 
H. pylori infection and preeclampsia
 27 March 2017 
Low-cost oral rotavirus vaccine
 27 March 2017 
 Clostridium difficile and colectomy risk in IBD
 24 March 2017 
MRI for local staging of colon cancer
 24 March 2017 
In-office communication about ulcerative colitis
 24 March 2017 
Prevalence of undiagnosed celiac disease
 23 March 2017 
Suspected nonceliac gluten sensitivity
 23 March 2017 
H. pylori and GERD in children
 23 March 2017 
Prespectives on the management of fecal incontinence
 22 March 2017 
Role of microbiota in colorectal surgery
 22 March 2017 
Disease activity in eosinophilic esophagitis
 22 March 2017 
Abdominal visceral fat and new erosive esophagitis
 21 March 2017 
Global trends in colorectal cancer mortality
 21 March 2017 
Pain in pancreatic cancer
 21 March 2017 
Hepatitis C virus–related hepatic myelopathy
 20 March 2017 
NASH treatment and MRI
 20 March 2017 
Metastasis in human colorectal cancer
 20 March 2017 
Fistula treatment of Crohn’s disease
 17 March 2017 
Microbiota in colorectal cancer 
 17 March 2017 
Among Persons with IBD
 17 March 2017 
Acute liver failure in Scotland
 16 March 2017 
Transition readiness scores in adolescents with IBD
 16 March 2017 
Hepatocellular carcinoma risk in different etiologies of cirrhosis
 16 March 2017 
IBD disability index
 15 March 2017 
European consensus on fecal microbiota transplantation 
 15 March 2017 
Hepatocellular carcinoma in the USA 
 15 March 2017 
Hospital readmission for ulcerative colitis
 14 March 2017 
Cardiovascular diseases risk in Barrett's
 14 March 2017 
Assessment of competence in colonoscopy
 14 March 2017 
Cholecystectomy to prevent recurrent pancreatitis
 13 March 2017 
Gallstone disease after colectomy for ulcerative colitis
 13 March 2017 
Achalasia in Chicago since high-resolution manometry
 13 March 2017 
Vedolizumab exposure in pregnancy
 10 March 2017 
Thiopurine therapy in IBD
 10 March 2017 
Complications in advanced fibrosis in Hep C eradication
 10 March 2017 
Intragastric balloons for obesity-related co-morbidities
 09 March 2017 
Intestinal tuberculosis vs Crohn's disease
 09 March 2017 
Predictors of relapse in children with IBD
 09 March 2017 
Direct-acting antiviral regimen for Hep C genotype 3 
 08 March 2017 
Sterile fecal filtrate transfer for C. diff
 08 March 2017 
Drug-induced liver injury
 08 March 2017 
Pharmacotherapy for alcohol dependence
 07 March 2017 
Psychotropic drugs in functional dyspepsia
 07 March 2017 
Vagus nerve and appetite regulation
 07 March 2017 
Gastrointestinal involvement in systemic sclerosis
 06 March 2017 
Small bowel abnormalities in IBS 
 06 March 2017 
Treatment response in NASH with MRI
 06 March 2017 
Intestinal bacterial overgrowth and PPIs in children
 03 March 2017 
Alcohol and risk of gallstone disease
 03 March 2017 
Smoking at colon cancer diagnosis influences survival
 03 March 2017 
Improvements in Crohn’s Disease outcomes over time
 02 March 2017 
Surviving sepsis guidelines
 02 March 2017 
Tenofovir and Hep B transmission in pregnancy
 02 March 2017 
Diagnosis of pediatric IBD 

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us