In this study, researchers from Japan clarified the prognostic value of distal intramural spread of tumor for survival and recurrence in patients with rectal cancer.
The team examined microscopic distal intramural spread was examined in 134 consecutive patients with resected rectal cancer.
|25% of patients had distal intramural spread.|
|Annals of Surgical Oncology|
They used univariate and multivariate analyses to correlate distal intramural spread, established clinicopathologic factors, and patients’ prognoses.
The researchers used American Joint Committee on Cancer classification and stage groupings for tumor assessment.
Researchers found that 25% of patients had distal intramural spread.
Multivariate logistical regression analysis revealed that T3/T4 and M1 were independent predictive variables for the presence of distal intramural spread.
In addition, patients with distal intramural spread had a shorter disease-specific or disease-free survival time after curative surgery than those without.
Furthermore, the researchers found that most patients with distal intramural spread developed distant recurrence.
Cox’s regression determined that distal intramural spread is an independent factor in predicting distant recurrence and worse outcomes after curative surgery in patients with rectal cancer.
Dr Tohru Nakagoe’s team concluded, “Distal intramural spread is an independent risk factor for distant metastasis and poor prognosis in patients with rectal cancer”.