In this study, an international team of researchers investigated whether micronutrient supplementation improved the vibriocidal antibody response to a killed oral cholera vaccine.
The team randomly assigned 25 children to receive either vitamin A and zinc (AZ group), vitamin A and a placebo (A group), zinc and a placebo (Z group), or both placebos (P group).
All children received 2 doses of the vaccine.
|Vitamin A supplementation was not found to have a significant effect.|
|Journal of Infectious Diseases|
The researchers found that the number of children with a 4-fold increase in vibriocidal antibody was significantly greater in the AZ group, compared to the P group.
The team also found that the proportion of children with a 4-fold increase in vibriocidal antibody was significantly greater in the zinc-supplemented groups.
Vitamin A supplementation was not found to have a significant effect.
Dr John Albert's team concluded, "Supplementation with zinc improves seroconversion to vibriocidal antibody and…has the potential to improve the efficacy of oral cholera vaccine in children".