In this study, researchers evaluated the spectrum of magnetic resonance (MR) imaging appearances of the liver in primary sclerosing cholangitis (PSC). They also examined the correlation of these images with clinical stage of disease.
The research team's findings are published in the March issue of Radiology.
|No correlation was found between imaging findings and clinical scores.|
Overall, 52 patients (25 female, 27 male; mean age, 43 years) with PSC underwent nonenhanced and gadolinium-enhanced MR imaging.
Following this, 2 abdominal radiologists retrospectively reviewed all images, first independently and then in consensus. They assessed the imaging pattern of the liver parenchyma, presence and grade of intrahepatic biliary ductal dilatation, and presence of areas of parenchymal atrophy or abnormal signal intensity and/or gadolinium enhancement.
The team then correlated the imaging findings with Child class, Child-Turcotte-Pugh score, and Mayo end-stage liver disease (MELD) score.
Of the 52 patients, 13% had no imaging findings of cirrhosis, 33% had a diffuse pattern of cirrhosis, and 54% had a large macronodular pattern.
Intrahepatic biliary ductal dilatation was observed in 85% patients. It was general in 35% and segmental in 50%.
In addition, peripheral wedge-shaped areas of parenchyma were observed with atrophy in 44% to 48% of patients, and without atrophy in 35% of patients.
The researchers found no correlation was found between imaging findings and clinical scores.
Dr Till Bader's team concluded, "The spectrum of MR imaging appearances of PSC is diverse and comprises distinct patterns that do not appear to correlate with severity of disease".
"Large regenerative nodules are a frequent finding and may help to establish the diagnosis."