In patients with uninvestigated dyspepsia who undergo endoscopy any abnormal findings guide management. However, upper endoscopy is "negative" in the majority of these patients.
In this study, researchers from Texas, USA, evaluated the impact of endoscopy on patient satisfaction in patients with uninvestigated dyspepsia.
The research team performed a secondary analysis of data obtained from a double-blind, randomized placebo-controlled trial.
In the study, a 6-week course of omeprazole versus placebo was evaluated in 140 patients with uninvestigated dyspepsia. Patients were followed for up to 1 year.
| Similar improvements in satisfaction were observed in subgroups with both negative and positive findings.|
Study participants were 18 years of age or older, with at least a 1-week history of dyspepsia without alarm features.
The team measured satisfaction at each visit, using a validated, reliable dyspepsia-related health measure, which included a satisfaction scale.
Patients unresponsive to empiric therapy with placebo or omeprazole underwent endoscopy.
The team analyzed satisfaction scores for 5 visits. Scores were measured twice before the day of endoscopy (time 1 and time 2), immediately before endoscopy (time 3), and twice after endoscopy (times 4 and 5).
The team determined that there was no difference in treatment failure rates between patients who received placebo or omeprazole. They combined the data from these groups.
The mean satisfaction scores for times 1 through 5, in all patients who underwent endoscopy were compared. Subgroups with positive and negative endoscopic findings were also compared.
Data for all 5 visits were available for 62 patients, 36 of whom had a negative endoscopy.
The research team found that, for all patients, the mean scores for time 2 (8.5) and time 3 (7.6) were significantly lower than those for times 4 (13.7) and (14.4).
In addition, the mean score for time 1 (11.1) was significantly lower than the mean score for time 5.
Furthermore, similar significant improvements in satisfaction scores were observed in subgroups with negative and positive findings.
Dr Linda Rabeneck's team concludes, "In patients with previously uninvestigated dyspepsia, endoscopy leads to improved patient satisfaction regardless of the endoscopic findings".