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 21 April 2018

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News

Prognosis can improve for patients with gastric cancer

Gastric cancer survival depends on stage at the time of diagnosis but, the longer the patient survives, the initial staging gets less and less relevant to final prognosis, find researchers in the February issue of Surgery.

News image

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The prognosis in gastric cancer is usually defined at the time of presentation. However, prognosis is a variable that alters with time.

Once a patient has survived for 1 year, their prognosis will change.

In this study, researchers from Japan, assessed prognosis in patients who have survived from 1 to 5 years after operation.

The research team examined 1468 patients with gastric cancer.

The relationship between stage and survival was altered by the passage of time.
Surgery
They looked at the next 5-year survival (5YS) of patients who already survived for 1, 2, 3, 4, and 5 years, after their initial operation. For patients who survived 1 year, the 5YS (the 6-year survival from operation) was calculated.

The team also determined similar survival for patients who had survived more than 2, 3, 4, or 5 years and reported according to stage.

The team found that in patients with stage III tumors who survived 2 years, the next 5YS was similar to that of patients in stage II at the time of diagnosis.

In patients who survived 3, 4, or 5 years, the next 5YS of patients in stage III b and stage III a was similar to that of patients in stage II, and subsequently improved.

Furthermore, the team found that the relationship between stage and survival was altered by the passage of time.

Improvement in survival from the 3rd, 4th, and 5th postoperative year was similar to the survival of patients at an earlier stage at the time of diagnosis.

Dr Yoshihiro Moriwaki's team concluded, "Survival is not only stage-dependent at the time of diagnosis but dependent on the length of survival from the initial operation".

"Progressive improvement in subsequent 5YS appears to approximate survival of lower-stage disease with the passage of time."

Surgery 2003: 133(2): 135-40
28 February 2003

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