In this study, researchers from Japan assessed risk factors for local tumor recurrence in patients with hepatocellular carcinoma (HCC). They also determined which patients were most suitable for a single session, single application of percutaneous radiofrequency (RF) ablation.
The research team enrolled 56 consecutive patients with 65 HCC tumors in this study.
Patients who received a single session, single application of percutaneous RF ablation and achieved optimal tumor ablation, were included.
The team assessed 6 possible factors for local recurrence using a Cox proportional hazards regression model. Factors were tumor size, tumor location, proximity of the tumor to intrahepatic large vessels, types of electrodes used, prior treatment, and observation of impedance rises.
In addition, local recurrence free intervals were estimated using the Kaplan-Meier method, and differences between groups were compared using the log-rank test.
|Tumor dimension > 2 cm and subcapsular location are associated local recurrence.|
The team found that the Kaplan-Meier estimates of overall cumulative local recurrence free intervals after a single treatment were 76% at 12 months, and 74% at 15 months.
In addition, the log-rank test showed a significant difference between the local recurrence free intervals according to tumor size and tumor location.
The team also determined, using Cox regression analysis, that a tumor dimension > 2 cm and subcapsular location were associated independently with local recurrence.
The remaining 4 factors were not associated with local recurrence.
Dr Yasuji Komorizono's team concluded, "A single session, single application of RF ablation produced favorable local control".
"Patients who have nonsubcapsular HCC tumors measuring 2 cm in greatest dimension may be the most suitable candidates for a single-session, single application of RF ablation."