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 26 May 2018

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Outcomes of colorectal cancer in the United States

Researchers in the February issue of the American Journal of Gastroenterology find that although advances in screening and treatment for colorectal cancer have been made, these have conferred no survival benefit.

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Important advances in colorectal cancer (CRC) screening and treatment have occurred in the past decade.

In this study, researchers from the United States evaluated temporal trends in CRC incidence and survival.

The research team assessed data from 9 population-based cancer registries. These registries constituted the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. They identified primary CRCs diagnosed between 1986 and 1997.

In addition, the team evaluated temporal changes from 1986 to 1988, 1989 to 1991, 1992 to 1994, and 1995 to 1997.

In white patients, age-adjusted incidence rates for rectosigmoid and left colorectal cancer fell over time.
American Journal of Gastroenterology

The team calculated age-adjusted incidence and relative 1-, 3-, and 5-yr survival.

Overall, the team identified 144,284 patients with CRC between 1986 to 1997. Of these patients, 52% were men.

They found that in white patients, the age-adjusted incidence rates for rectosigmoid and left CRC fell over time. In addition, in white men, the age-adjusted incidence rates for right CRC declined.

However, in black patients, the age-adjusted incidence rates for rectosigmoid and right CRC showed no significant change over time.

The team did not identify a significant difference in survival in whites or blacks.

Dr Linda Rabeneck's team concluded, "The decrease in age-adjusted incidence rates over time is consistent with a decrease in CRC burden, especially among whites".

"However, the lack of improvement in survival over time in whites and blacks indicates that despite advances in screening and treatment, to date, no survival benefit has occurred."

Am J Gastroenterol 2003; 98(2): 471-7
17 February 2003

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