Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 28 May 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Resection after preoperative chemoradiotherapy in unresectable pancreatic cancer

Preoperative treatment with chemotherapy and radiotherapy in patients with unresectable pancreatic cancer is feasible, find researchers in the latest issue of the American Journal of Clinical Oncology.

News image

fiogf49gjkf04

Simultaneous chemoradiation is used in unresectable pancreatic cancer for palliation.

However, it is not known if the use of adjuvant surgery will benefit this group of patients.

In this study, researchers from Spain treated 47 patients with unresectable pancreatic cancer, using simultaneous preoperative radiation therapy (45 Gy) and chemotherapy between 1991 and 1998.

The chemotherapy followed 3 different protocols: cisplatin, 5-fluorouracil plus or minus paclitaxel; cisplatin, 5-fluorouracil (protracted infusion); and docetaxel and gemcitabine.

The team performed a Whipple pancreatoduodenectomy 1 month after the end of radiation, in patients selected for resection.

12 patients were considered to have clinically resectable tumors after the preoperative treatment.
American Journal of Clinical Oncology

Following preoperative treatment 23 patients with unresectable tumors received an additional dose (10 to 12 Gy) of radiotherapy.

The research team found that 12 patients were considered to have clinically resectable tumors after the preoperative treatment. Of these, 9 patients had surgery, and 2 had complete pathologic response.

However, after chemoradiation, 2 patients died of pneumonia and GI, and a further 2 patients died in the postoperative period.

Local recurrence was observed in 22% of the patients, and 57% had distant metastases.

The team found that 3-year survival rates for patients with unresectable and resectable tumors were 0% and 48%, respectively.

Dr Javier Aristu’s team concluded, “Preoperative treatment with chemotherapy and radiotherapy in patients with unresectable pancreatic cancer is feasible”.

“In some patients, the tumor can be resected, and in addition some cases of complete pathologic response were found.”

“Long-term survivors were observed in the group of resected tumors.”

“More effective chemotherapy regimens are needed because the majority of the patients died of metastatic disease.”

Am J Clin Oncol 2003; 26(1): 30-36
12 February 2003

Go to top of page Email this page Email this page to a colleague

 28 May 2018 
Therapeutic strategies for HCV
 28 May 2018 
Mesalazine in ulcerative colitis
 28 May 2018 
Technology and management of digestive diseases
 25 May 2018 
Technology to increase colorectal cancer screening
 25 May 2018 
Post‐operative complications in elderly IBD
 25 May 2018 
Colorectal cancer–specific mortality
 24 May 2018 
Alcohol consumption and outcomes in drug-induced liver injury
 24 May 2018 
Patient-reported outcome measures in IBD trials
 24 May 2018 
Precision medicine for tumors
 23 May 2018 
Management of perianal fistulas in Crohn’s disease
 23 May 2018 
Cardiovascular risk in diabetes mellitus with NAFLD
 23 May 2018 
High body mass index is and ulcerative colitis
 22 May 2018 
Worldwide H.pylori prevalence
 22 May 2018 
PPI and risk of stroke
 22 May 2018 
Online tool predicts bowel dysfunction severity prior to anterior resection
 21 May 2018 
PPI use and cognitive decline
 21 May 2018 
Depressive symptoms in IBD youth
 21 May 2018 
Fecal incontinence and quality of life in IBD
 18 May 2018 
Esophageal dilatation in clinical practice 
 17 May 2018 
IBD and later extraintestinal manifestations
 17 May 2018 
Repeat stool DNA testing
 17 May 2018 
IBS and chronic fatigue following GI infection
 16 May 2018 
Factors associated with fecal incontinence
 16 May 2018 
Diagnostic delay in Crohn's disease
 16 May 2018 
Cardiovascular risk in diabetes mellitus with NAFLD
 15 May 2018 
Guidelines for management of Crohn's
 15 May 2018 
New therapies for CDI
 15 May 2018 
Hep B in the Grey Zone
 14 May 2018 
Blood test for the diagnosis of fibrotic NASH
 14 May 2018 
Outcomes at bariatric centers of excellence
 14 May 2018 
Management of perianal fistulas in Crohn’s
 11 May 2018 
Detection of undiagnosed celiac disease
 11 May 2018 
Alcohol consumption and drug-induced liver injury
 10 May 2018 
Colorectal cancer screening
 10 May 2018 
Fibrosis in patients with chronic hepatitis B
 09 May 2018 
Fecal incontinence
 09 May 2018 
Health problems and IBS
 09 May 2018 
Esophageal dilatation in clinical practice 
 07 May 2018 
Omitting antibiotics in uncomplicated acute diverticulitis
 07 May 2018 
Health problems and IBS
 07 May 2018 
Assessment of diminutive colorectal polyps
 04 May 2018 
National Institutes of Health workshop and obesity
 04 May 2018 
Factors associated with fecal incontinence
 04 May 2018 
Colorectal cancer screening and ethnic inequities
 03 May 2018 
Gastrointestinal ultrasound in IBD
 03 May 2018 
Ultransonography in postsurgical recurrence in Crohn's
 02 May 2018 
Symptom assessment in cirrhotic ascites
 02 May 2018 
Hep C antiviral treatment and liver cancer risk
 02 May 2018 
Chronic Hep B
 01 May 2018 
European guidelines on pancreatic cystic neoplasms
 01 May 2018 
Interferon‐free regimens in Hep C
 01 May 2018 
Age at IBD onset and extraintestinal complications
 30 April 2018 
Formula for preterm infants
 30 April 2018 
Primary antibiotic resistance and sequential therapy for H. pylori
 27 April 2018 
Eastern and western practices for endoscopic resection of colorectal lesions
 27 April 2018 
Anxiety scale for chronic esophageal disease
 27 April 2018 
Disease activity in eosinophilic esophagitis
 26 April 2018 
Obesity and physical activity in diverticulosis
 26 April 2018 
Primary sclerosing cholangitis in the USA
 25 April 2018 
Aspirin and pancreatic cancer

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us